This is the Web Implementation of the tools detailed
in a manuscript by Colantuoni
et al. (Bioinformatics, 2002 Nov;18(11):1540-1).
"SNOMAD (Standardization and NOrmalization
of MicroArray Data): Web-accessible Gene Expression Data Analysis"
SNOMAD is a program for the standardization and normalization of gene
expression datasets. In addition to conventional transformations and
visualization tools, SNOMAD includes two non-linear transformations
which correct for bias and variance which are non-uniformly distributed
across the range of microarray element signal intensities: local mean
normalization and local variance correction (Z-score generation using
a locally calculated standard deviation).
It is written as a perl script using the R language and environment
and can be run over the internet from the Pevsner Lab Server.
Alternatively you can download the program and run it locally under the UNIX operating
system (requires the R Project Software).
SNOMAD is Copyrighted (C) 2000 by Carlo Colantuoni,
George Henry, Jonathan Pevsner and is distributed under the terms
of the
GNU General Public
License and comes with ABSOLUTELY NO WARRANTY. This is free
software, and you are welcome to redistribute it under certain conditions:
see
details.
